DOHENY EYE INSTITUTE
PO BOX 86228, LOS ANGELES, CA 90086 www.doheny.org

---

Organizations Filed Purposes: TO FURTHER THE CONSERVATION, IMPROVEMENT AND RESTORATION OF HUMAN EYESIGHT.

THE MISSION OF THE DOHENY EYE INSTITUTE (DEI), TO FURTHER THE CONSERVATION, IMPROVEMENT AND RESTORATION OF HUMAN EYESIGHT, IS GUIDED BY THE FOLLOWING OBJECTIVES: 1. TO INCREASE KNOWLEDGE OF THE HUMAN EYE, ITS CONDITIONS AND DISEASES, THROUGH RESEARCH; 2. TO TRANSMIT THIS KNOWLEDGE THROUGH EDUCATION, TRAINING, AND COMMUNITY SERVICE; AND 3. TO FACILITATE THE APPLICATION OF ITS RESEARCH TO IMPROVE PATIENT CARE AND FOSTER FURTHER RESEARCH. RESEARCH ACTIVITIES FOR THE PERIOD AND SELECTED FOR LONG-TERM FOCUS INCLUDE: RETINAL AND MACULAR DEGENERATION RESEARCH THROUGH THE STUDY OF RETINAL PIGMENT EPITHELIUM, RETINAL CELL TRANSPLANTATION, MOLECULAR GENETICS OF INHERITED DISEASES OF THE RETINA AND GENE THERAPY FOR RETINAL DISORDERS; MODIFICATION OF CORNEAL SHAPE AND MORPHOLOGY THROUGH CORNEAL RESEARCH AND REFRACTIVE SURGERY INNOVATIONS; AND REGENERATION OF DAMAGED OPTIC NERVE. On December 18, 2013, the Doheny Eye Institute executed an agreement with the University of California at Los Angeles (UCLA) for a 99 year affiliation. The purpose of this affiliation is to carry out the Institute's mission -- to further the conservation, improvement, and restoration of human eyesight -- through research, education, and clinical care (clinical care is provided directly by UCLA). Both the Institute and UCLA-Stein Eye Institute are dedicated to providing the public with the highest quality of ophthalmic care and the most innovative and strategic research for the improvement of human eyesight. New Areas of Research DEIs glaucoma clinician scientist has research projects that include the use of optical coherence tomography, and the angiographic visualization of aqueous humor outflow in the eye. NASA recently announced the selection of his study as part of their plan to support astronaut vision health for missions to the moon and Mars; DEI has proposed a novel countermeasure approach to prevent the development of optic disc edema, with part of the study to be conducted in a state of the art, ground-based, spaceflight analog facility in Cologne, Germany. DEI has developed a pioneering Adaptive Optics imaging instrument that integrates scanning laser ophthalmoscopy and optical coherence tomography (AO-SLO-OCT). This instrument can image the retina with a 3-D spatial resolution of 2.5 m x 2.5 m x 5 m, allowing for in-vivo ultrastructure assessment of reticular pseudodrusen and individual photoreceptors in both en face and cross-sectional planes. This Adaptive Optics imaging overcomes the limitations presented by optical defects in living eyes, allowing for high resolution images of the choriocapillaris in the study of various chorioretinal diseases, including Age-Related Macular Degeneration. DEI is using calcium imaging with confocal microscopy to characterize the effects of oxidative stress on the retinal ganglion cells to identify the early, emerging deficits in their electrophysiological function resulting from mitochondrial dysfunction. By carefully analyzing even the earliest signs of changes to photoreceptor response waveform and synaptic output to bipolar cells, their detection and interpretation could lead to diagnostic clues that warn of dysfunction and act to aid detection of persons at higher risk. DEI is researching the early stages of inflammation mediated degeneration of blood vessels, focusing on the atrophy of retinal vessels in Diabetic Retinopathy and the choriocapillaris/choroid in Age-Related Macular Degeneration. This integration of the principles of diabetes, retinal inflammation, vascular mechanobiology, and clinical trial treatment has led to a unique interdisciplinary approach that has the potential to identify other previously unrecognized mechanochemical mechanisms underlying DR pathogenesis.

---

---

Data for this page was sourced from XML published by IRS (public 990 form dataset) from: https://s3.amazonaws.com/irs-form-990/202111319349302241_public.xml