PACIFIC HEART LUNG AND BLOOD INSTITUTE
10780 Santa Monica Blvd 101, Los Angeles, CA 90025 www.phlbi.org

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Organizations Filed Purposes: THE PACIFIC HEART, LUNG & BLOOD INSTITUTETHE MISSION OF THE PACIFIC HEART, LUNG & BLOOD INSTITUTE IS TO SERVE AS A CENTER OF CROSS-DISCIPLINARY SCIENTIFIC RESEARCH THAT SIGNIFICANTLY CONTRIBUTES TO DISCOVERIES OF NEW TREATMENTS FOR HEART, LUNG, AND BLOOD DISEASES, AND TO PROVIDE A PLATFORM FOR MEDICAL EDUCATION FOR BOTH CONSUMERS AND PROFESSIONALS THAT IMPROVES ACCESSIBILITY TO EFFECTIVE TREATMENTS OF THESE DISEASES AND ENHANCES PREVENTION OF THESE CONDITIONS IN THE GENERAL POPULATION.THE PACIFIC MESO CENTERMISSION: THE PACIFIC MESO CENTERS MISSION IS TO BETTER SERVE MESOTHELIOMA PATIENTS THROUGHOUT THE UNITED STATES BY SUPPORTING THE FIRST-OF-ITS-KIND NATIONAL RESEARCH INSTITUTE DESIGNED TO IMPROVE THEIR LONGEVITY AND QUALITY OF LIFE, AND TO DISCOVER INNOVATIVE THERAPIES OF APPROACHING MALIGNANT PLEURAL MESOTHELIOMA (MPM) AS A CHRONIC, TREATABLE DISEASE.

SCIENTIFIC RESEARCH TO DEVELOP NEW TREATMENTS FOR HEART, LUNG, AND BLOOD DISEASES

The Pacific Heart, Lung & Blood Institute (PHLBI) focuses on orphan diseases of the heart, lung and blood that receive little attention and funding. One of the divisions of PHLBI, The Pacific Mesothelioma Center (PMC), is currently developing cancer therapies using mesenchymal stem cells (MSCs) derived from placenta and bone marrow. These cells are modified to express large amounts of Interleukin 12, which stimulates the immune system to reject cancer cells. We were awarded a patent for our mesenchymal stem cells in 2018.Our two world-class research scientists, Dr. Masahide Tone and Dr. Yukiko Tone continue their important investigative research. Masahide Tone who received his PhD at Tohoku University in Japan and his wife Yukiko Tone received her DSc at Tokyo Metropolitan University in Japan. Both scientists have worked at the universities of Cambridge and Oxford in the UK, and the University of Pennsylvania and Cedars Sinai Medical Center in Los Angeles. They continue to collaborate with our Scientific Advisor, Dr. Robert B. Cameron, MD, FACS, who is Professor of Thoracic Surgery, Surgical Oncology at UCLA, Director of the UCLA Mesothelioma Comprehensive Research Program at the David Geffen School of Medicine at UCLA, and Chief of Thoracic Surgery at the West Los Angeles Veterans Administration.A strength in our institute is that the clinical and research teams are directly connected, allowing us access to patient specimens for our tissue bank, which is the best environment in which to develop cancer immunotherapy strategies. This positions us favorably over other research institutions for research breakthroughs. Establishing new therapeutic strategies is our highest priority. PHLBI has the added advantage of having its own in-house research lab. in Santa Monica.We are also proud to continue supporting our International Symposiums on Malignant Pleural Mesothelioma. The symposiums give unrivaled opportunities both to the medically savvy and to the general public, including mesothelioma patients, to not only learn first-hand about groundbreaking discoveries, but also to exchange ideas.AdvocacyThe PMC strives for a healthy America by advocating for a carcinogen-free environment, informing the public about the use of asbestos in America, and mobilizing the public to ensure asbestos reform through a complete and total ban.Caregiver Support GroupThis marks the fourth year since PMC began offering monthly patient support group meetings. The support group led by PMC Nurse Practitioner Lien Hua-Feng and coordinated by Christina McSherry was created to give mesothelioma patients an outlet to ask questions, share stories, and release difficult emotions. The group helps patients connect with other patients who can directly relate to their experiences.International Tissue BankThe PHLBI received Institutional Review Board (IRB) approval in 2016 for its international tissue bank. Diseases of the heart, lung and blood affect a large number of people in the U.S. and throughout the world each year. It is imperative that both personal health information and tissue samples are collected from as many patients as possible in order to understand: The normal tissue biology The natural history of the disease Outcomes from current treatments The advantages and disadvantages of potential future novel therapies. PHLBI is soliciting tissue specimens and seeks study participants who wish to donate their tissue and personal health information for current and future research at the institute.Student Internship ProgramPHLBI provides undergraduate student interns from UCLA early career training and mentorship in medical research. Our interns are given hands-on educational opportunities that are difficult to obtain at their host universities as undergraduate students. University research labs are often constrained by limited budgets, where resources are typically prioritized for post-doctoral fellows and graduate students pursuing advanced degrees. At PHLBI, our interns have the unique opportunity to gain real-world experience and fill meaningful roles in medical research at a young age. In return, PHLBIs core mission of conducting cancer immunotherapy research benefits from their involvement.

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