| ANMED HEALTH | $617,480,348 | $584,577,860 |
| ANDERSON UNIVERSITY | $102,222,517 | $96,439,153 |
| HOSPICE OF THE UPSTATE INC | $9,625,408 | $9,377,924 |
| SENIOR SOLUTIONS | $8,896,980 | $8,211,318 |
| ANDERSON FREE CLINIC | $5,779,260 | $5,710,262 |
| NEW FOUNDATIONS HOME FOR CHILDREN | $5,395,379 | $5,163,594 |
| HAVEN OF REST RESCUE MISSION | $4,623,931 | $4,683,819 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF ANDERSON SOUTH CAROLINA | $4,367,499 | $4,046,286 |
| ANMED HEALTH FOUNDATION | $2,315,913 | $2,709,116 |
| ANDERSON INTERFAITH MINISTRIES | $3,007,681 | $2,686,648 |
| FOOTHILLS COMMUNITY FOUNDATION | $2,761,603 | $2,431,612 |
| UNITED WAY OF ANDERSON COUNTY | $2,130,636 | $1,780,173 |
| HABITAT FOR HUMANITY OF ANDERSON INC | $1,785,415 | $1,675,449 |
| MONTESSORI SCHOOL OF ANDERSON | $1,394,020 | $1,626,521 |
| ANDERSON CHRISTIAN SCHOOL INC | $1,188,092 | $1,239,774 |
| MEALS ON WHEELS INC | $1,606,317 | $1,104,064 |
| FOOTHILLS ALLIANCE | $991,734 | $1,047,698 |
| CT TOWNSEND MINISTRIES INC | $1,066,120 | $1,004,275 |
| CALVARY HOME FOR CHILDREN | $1,201,993 | $994,939 |
| DEVELOPMENTAL CENTER FOR EXCEPTIONAL CHILDREN | $792,691 | $710,687 |
| ANDERSON COUNTY ARTS COUNCIL | $507,015 | $611,806 |
| ANDERSON CHAMBER OF COMMERCE | $568,162 | $587,026 |
| CANCER ASSOCIATION OF ANDERSON | $613,985 | $583,523 |
| BIG DOG FOUNDATION INC | $486,075 | $495,072 |
| BAPTIST EDUCATIONAL AND MISSIONARY SERVICES INC | $535,172 | $492,964 |