MORGRIDGE INSTITUTE FOR RESEARCH INC
330 N ORCHARD STREET, MADISON, WI 537151119 morgridge.org

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Organizations Filed Purposes: OUR MISSION IS TO IMPROVE HUMAN HEALTH BY CONDUCTING, ENABLING AND TRANSLATING INNOVATIVE, INTERDISCIPLINARY BIOMEDICAL RESEARCH IN PARTNERSHIP WITH THE UNIVERSITY OF WISCONSIN-MADISON AND OTHERS, BY LEVERAGING OUR COLLECTIVE STRENGTH IN RESEARCH AND EDUCATION.OUR VISION IS TO SOLVE MAJOR CHALLENGES TO HUMAN HEALTH BY SERVING AS AN INTERDISCIPLINARY RESEARCH CENTER AND COLLABORATIVE HUB THAT ENABLES INVESTIGATORS TO ADDRESS AND ANSWER FUNDAMENTAL BIOMEDICAL QUESTIONS.WE ENVISION USING OUR PRIVATE STATUS AND STREAMLINED ORGANIZATIONAL STRUCTURE TO RESPOND NIMBLY TO EMERGING OPPORTUNITIES. IN PARTNERSHIP WITH AN OUTSTANDING PUBLIC RESEARCH UNIVERSITY WE WILL SYNERGISTICALLY ENHANCE OUR COLLECTIVE STRENGTHS.THROUGH COMMUNITY ENGAGEMENT WE WILL PROMOTE BETTER UNDERSTANDING OF THE HEALTH BENEFITS OF BIOMEDICAL RESEARCH.

RESEARCH INSTITUTE TO SUPPORT MEDICAL RESEARCH AND EDUCATION AT THE UNIVERSITY OF WISCONSIN-MADISON IN CONJUNCTION WITH THE UNIVERSITY OF WISCONSIN HOSPITALS AND CLINICS AUTHORITY. THE PRIMARY PURPOSES FOR THE INSTITUTE ARE AS FOLLOWS:1) COLLABORATION - SPARK RESEARCH COLLABORATIONS ACROSS THE SCIENCES AND THE UW-HOSPITAL THAT ACCELERATE BREAKTHROUGH DISCOVERIES TO IMPROVE HUMAN HEALTH.2) INTERACTION - FOSTER INTERACTION BETWEEN PUBLIC AND PRIVATE RESEARCH THAT BREAKS DOWN BARRIERS BETWEEN RESEARCHERS, LABS AND SCIENTIFIC DISCIPLINES.

REGENERATIVE BIOLOGY: UNDERSTANDING AND DIRECTING CELLULAR FATES TO IMPROVE HEALTH- CREATE PHYSIOLOGICALLY STABLE, SAFE AND FUNCTIONAL CELLS TO BETTER UNDERSTAND THE HUMAN BODY.- APPLY KNOWLEDGE ABOUT CELLUAR GENERATION FOR APPLICATION IN PREVENTION AND TREATMENT OF DEGENERATIVE DISEASES.- APPLY KNOWLEDGE TO DEVELOP AND TAILOR DRUGS FOR SPECIFIC NEEDS.

MEDICAL ENGINEERING: ADVANCING TECHNOLOGIES TO BETTER DIAGNOSE, TREAT AND PREVENT DISEASE-TRANSIENT LIGHTING FOR SURGERY: DEVELOPMENT OF A RAPID-SWITCH LIGHTING SYSTEM THAT PROVIDES FULL LIGHT IN THE OPERATING ROOM, WHILE PROTECTING LIGHT-SENSITIVE FLUORESCENCE IMAGES OF USE TO SURGEONS.-BETTER CT IMAGES: DEVELOPING A MULTI-SOURCE X-RAY TUBE FOR COMPUTED TOMOGRAPHY (CT) - ONE OF THE MOST WIDELY USED TOOLS TO IMAGE DISEASE - TO ENABLE FASTER IMAGING, DOSE REDUCTION, AND IMPROVED IMAGE QUALITY.-IMPROVED BREAST CANCER TRACKING: CREATING AN IMAGING SYSTEM TO TRACK BREAST CANCER BASED ON ALIGNMENT OF COLLAGEN FIBERS, WHICH ARE BIOMARKERS FOR BREAST CANCER METASTASIS.

METABOLISM: - ELUCIDATING THE CHEMISTRY OF LIFE AND ITS DISRUPTION IN HUMAN DISEASE- MITOCHONDRIA AND DISEASE: UNLOCKING FUNCTION OF THE MITOCHONDRIA, OR "CELLULAR POWERHOUSE," TO UNDERSTAND ITS ROLE IN MORE THAN 150 DISEASES, INCLUDING PARKINSON'S, DIABETES, AND CANCER. - ORPHAN PROTEINS: ESTABLISHING A RESEARCH PLATFORM TO STUDY THE MORE THAN 100 PROTEINS - NEARLY ONE-QUARTER OF THE MAMMALIAN MITOCHONDRIAL PROTEOME - THAT HAVE A YET UNDISCOVERED BIOCHEMICAL FUNCTION.- COENZYME Q: INTEGRATING VARIOUS BIOCHEMICAL, GENETIC AND STRUCTURAL BIOLOGY APPROACHES TO FURTHER ELUCIDATE THE STEPS OF COENZYME Q, WHOSE DEFICIENCY IS ASSOCIATED WITH MULTIPLE HUMAN DISEASES.

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