| CARILION MEDICAL CENTER | $1,489,550,023 | $1,382,660,716 |
| DELTA DENTAL OF VIRGINIA | $730,806,957 | $711,628,850 |
| CARILION SERVICES INC | $285,536,868 | $279,988,354 |
| CARILION NEW RIVER VALLEY MEDICAL CENTER | $259,715,753 | $211,681,591 |
| GOODWILL INDUSTRIES OF THE VALLEY WORKS | $73,534,458 | $76,400,961 |
| HOLLINS UNIVERSITY CORPORATION | $57,553,783 | $58,229,653 |
| KISSITO HEALTHCARE INC AND AFFILIATES | $49,280,393 | $48,478,861 |
| CARILION FRANKLIN MEMORIAL HOSPITAL | $52,532,680 | $47,558,836 |
| CARILION STONEWALL JACKSON HOSPITAL | $46,106,852 | $42,617,790 |
| CARILION GILES COMMUNITY HOSPITAL | $36,289,651 | $36,056,965 |
| LUTHERAN FAMILY SERVICES OF VIRGINIA INC | $39,332,196 | $35,885,763 |
| CARILION CLINIC | $42,773,392 | $28,447,524 |
| VIRGINIA LUTHERAN HOMES INC | $27,892,608 | $23,811,165 |
| CORVESTA INC | $5,454,848 | $23,622,964 |
| FRIENDSHIP HEALTH AND REHAB CENTER INC | $22,802,235 | $22,646,139 |
| DEPAUL COMMUNITY RESOURCES | $21,602,662 | $21,678,594 |
| TOTAL ACTION AGAINST POVERTY IN THE ROANOKE VALLEY | $21,520,083 | $20,737,701 |
| CARILION TAZEWELL COMMUNITY HOSPITAL | $15,768,842 | $18,683,717 |
| VIRGINIA TECH CARILION SCHOOL OF MEDICINE INC | $9,183,489 | $17,522,493 |
| GOODWILL INDUSTRIES OF THE VALLEYS INC | $28,530,557 | $15,998,455 |
| FRIENDSHIP HEALTH AND REHAB CENTER SOUTH | $14,079,060 | $13,976,938 |
| OUR LADY OF HOPE HEALTH CENTER INC | $14,829,020 | $13,406,133 |
| NORTH CROSS SCHOOL | $14,183,345 | $12,060,945 |
| OUR LADY OF THE VALLEY INC | $11,550,537 | $10,751,979 |
| BLUE EAGLE CREDIT UNION | $11,439,049 | $10,384,529 |