| CARILION MEDICAL CENTER | $1,489,550,023 | $1,382,660,716 |
| DELTA DENTAL OF VIRGINIA | $730,806,957 | $711,628,850 |
| CARILION SERVICES INC | $285,536,868 | $279,988,354 |
| CARILION NEW RIVER VALLEY MEDICAL CENTER | $259,715,753 | $211,681,591 |
| AMITY FELLOWSERVE INC | $68,617,930 | $93,627,131 |
| GOODWILL INDUSTRIES OF THE VALLEY WORKS | $81,982,583 | $79,305,687 |
| HOLLINS UNIVERSITY CORPORATION | $55,719,065 | $55,954,890 |
| CARILION FRANKLIN MEMORIAL HOSPITAL | $52,532,680 | $47,558,836 |
| CARILION STONEWALL JACKSON HOSPITAL | $46,106,852 | $42,617,790 |
| LUTHERAN FAMILY SERVICES OF VIRGINIA INC | $36,194,061 | $36,376,933 |
| CARILION GILES COMMUNITY HOSPITAL | $36,289,651 | $36,056,965 |
| CARILION CLINIC | $42,773,392 | $28,447,524 |
| VIRGINIA LUTHERAN HOMES INC | $27,892,608 | $23,811,165 |
| FRIENDSHIP HEALTH AND REHAB CENTER INC | $22,395,332 | $22,816,322 |
| CORVESTA INC | $582,468 | $22,012,995 |
| DEPAUL COMMUNITY RESOURCES | $21,148,791 | $20,847,338 |
| TOTAL ACTION AGAINST POVERTY IN THE ROANOKE VALLEY | $20,011,560 | $20,199,078 |
| CARILION TAZEWELL COMMUNITY HOSPITAL | $15,768,842 | $18,683,717 |
| GOODWILL INDUSTRIES OF THE VALLEYS INC | $19,234,034 | $18,040,308 |
| FRIENDSHIP HEALTH AND REHAB CENTER SOUTH | $13,463,563 | $13,865,586 |
| OUR LADY OF HOPE HEALTH CENTER INC | $12,232,314 | $11,352,175 |
| NORTH CROSS SCHOOL | $17,982,358 | $11,023,646 |
| BLUE EAGLE CREDIT UNION | $11,439,049 | $10,384,529 |
| OUR LADY OF THE VALLEY INC | $12,049,490 | $10,163,621 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF VIRGINIAS BLUE RIDGE INC | $9,570,437 | $9,548,408 |